Alpha and Omega follows Kate, a disciplined alpha wolf, and Humphrey, an easygoing omega, after park rangers relocate them far from their Jasper Park home. The mismatched pair must travel back before conflict between rival packs threatens their community. Hayden Panettiere and Justin Long voice Kate and Humphrey, with Dennis Hopper, Danny Glover, Christina Ricci and Larry Miller among the supporting voice cast.
Anthony Bell and Ben Gluck directed from a screenplay by Steve Moore and Christopher Denk. Lionsgate opened the animated adventure in Los Angeles and New York on September 17, 2010. AFI and Apple record an 88-minute PG-rated theatrical version, while Prime Video currently labels its transactional presentation as approximately 84 minutes, so the displayed runtime can vary by storefront or edition.