Squidbillies is an American adult animated television series that premiered in 2005. The show is about the adventures of the Cuyler family, who are squids living in the Appalachian Mountains. The characters often get into strange and humorous situations while dealing with issues like poverty, politics, and family relationships.

The world knows and loves Matt Groening for his unprecedented and unparalleled work on "The Simpsons." During the Fox Network's ambitious "Animation Domination" initiative, Groening teamed with David Cohen, creating a second hit animated series, "Futurama." Groening and Cohen described their wonderwork as "retrofuturistic," an amazingly apt oxymoron for a working class sitcom set in the thirty-first century. Apparently, blue collar labor will not evolve over the next thousand years: In "Futurama," a late 20th century pizza delivery guy is accidentally cryogenically frozen for a millennium; when he thaws and returns to consciousness, he finds a job at Planet Express, an inter-planetary delivery company. Not especially concerned with science, the writers focus the stories on the workplace trials and tribulations of the three central characters"”Fry, Leela, and Bender. Their future dramas strangely resemble every working person's today dramas. Although "Futurama" has moved up and down the dial, exiting Fox for Cartoon Network, and bidding farewell to Cartoon Network for a new home on "Comedy Central," it has held onto a fiercely loyal audience, and it especially has garnered unprecedented critical acclaim. In 2010, "Futurama" set a Guiness World Record for "Current Most Critically-Acclaimed Animated Series", adding to its eight Emmys and thirteen Annies.

Although the producers of "Family Guy" claim that it represents a "dysfunctional" family, millions of American viewers say it looks perfectly representative of most of the families in their neighborhood. Part of the "animation domination" line-up on Fox Network, "Family Guy" dramatizes the everyday dramas in the lives of Peter and Lois Griffin, their children Meg, Chris, and Stewie, and their dog Brian. Like all Seth MacFarlane productions, "Family Guy" depends on scathing satire of American popular culture for most of its humor, stretching the "plausible impossible" to make the baby and the dog by far the smartest and most perceptive among the members of the family. The Griffins have garnered three Emmys and three Annies for MacFarlane and company, and they have earned one Golden Reel Award. In 2009, "Family Guy" earned an Emmy nomination for Outstanding Comedy Series"”the first time since "The Flintstones" were nominated in 1962 that an animated series had numbered among the nominees.

Sealab 2021 was an American animated television series that aired on Adult Swim from 2000 to 2005. The show was a parody of the 1970s animated series Sealab 2020, which was about a research facility on the ocean floor. Sealab 2021 reuses the original footage from Sealab 2020 and combines it with new animation and comedic voiceovers to create a completely different show.

"Ed, Edd n Eddy" is a popular animated TV series that first aired in 1999. The show follows the adventures of three young boys, all named Ed, Edd, and Eddy, who live in a suburban cul-de-sac. The boys come up with various schemes to make money and have fun, often leading to comedic mishaps and misadventures.

Curious George is a TV series based on the popular children's book character of the same name. The show was first aired in 2006 and has since become a favorite among young viewers. The series follows the adventures of a mischievous and curious monkey named George, who lives with his friend, The Man with the Yellow Hat, in a big city.