Marmaduke will always find a way to stand out. When his owner, Phil (Lee Pace) and Debbie (Judy Greer) and her three children, move from the Midwest to California's Orange County, a German dog is sure that many adventures await him. Especially since the new boss Phil, Don Twombly (William H. Macy), a dog freak and arranges business meetings at the dog park. The first new friend if Marmaduke is Russian cat named Carlos. And both prove that dogs and cats can live under one roof in harmony. Carlos has always supported Marmaduke'a, even the wildest ideas, to help in locating Phil's family in the new place of residence. First days in Orange County are fantastic. Marmaduke rides with his master around the city, issued by the sunroof head and wears sunglasses. He meets a bunch of Pedigree. To buy in its favor, in the absence of its owner, invites her to a party. The only witness to uncontrollable events is Carlos.