Common Side Effects is an adult animated thriller-comedy created by Joseph Bennett and Steve Hely for Adult Swim, executive produced by Mike Judge and Greg Daniels through their Bandera Entertainment. The story follows Marshall Cuso, an eccentric, burned-out mycologist who discovers a rare mushroom capable of healing almost any ailment — even reversing death. When he reconnects with a former high-school classmate now working at a pharmaceutical giant, his miraculous find sets off a dangerous chase as powerful interests scramble to control, suppress, or exploit it.
Rendered in a lush, hand-drawn style far removed from typical adult cartoons, the series pairs paranoid conspiracy-thriller plotting with dry humor and surprising sincerity about health care, grief, and corporate greed. Dave King and Emily Pendergast lead the voice cast as Marshall and the conflicted pharma executive Frances, with Mike Judge, Danny Huston, and Joseph Lee Anderson among the supporting players, giving the show both comedic bite and genuine tension.
Debuting on Adult Swim in early 2025 and streaming on HBO Max, Common Side Effects became one of the most acclaimed animated series of the year, earning a rare wave of critical enthusiasm and a second-season renewal before its first season had even finished airing. It streams on HBO Max.
"Animals." is an animated comedy series that follows the lives of different animals living in New York City. The show uses humor to explore topics like politics, relationships, and environmental issues.
Each episode of "Animals" features a different group of animals and their daily struggles in the city. The animals are voiced by a talented cast of comedians, such as Jason Mantzoukas and Aziz Ansari. The show's animation style is unique, which adds to its charm and appeal.
If you're a fan of adult animation or comedy shows that aren't afraid to touch on serious topics, "Animals." might be the perfect show for you. You can stream the show on Hulu, and if you're not a subscriber yet, you can sign up for a free trial to check it out. "Animals." is a funny and thought-provoking show that is sure to entertain and make you think.
"Frisky Dingo" is an animated television series that aired on Adult Swim from 2006 to 2008. The show is a satirical take on superhero and supervillain tropes, following the story of a billionaire named Xander Crews who becomes the superhero "Awesome-X" to fight against the supervillain "Killface" and his plans to destroy the world.
The show was created by Adam Reed and Matt Thompson, who would later go on to create the popular animated series "Archer." "Frisky Dingo" was praised for its humor and clever writing, which poked fun at both the superhero genre and modern society as a whole. The show also featured unique animation and art design, which helped set it apart from other animated series at the time.
Despite its critical success, "Frisky Dingo" was canceled after two seasons due to low ratings. However, the show gained a cult following after its cancellation and has since been regarded as a classic of Adult Swim's programming. The show's influence can also be seen in later animated series, including "Archer" and "Rick and Morty," both of which were created by former "Frisky Dingo" writers.
"The Jellies!" is a comedy animated television series created by Tyler, The Creator and Lionel Boyce. The show follows a family of jellyfish who live in Walla Walla, Washington, as they navigate their daily lives. The main character is Cornell Jelly, a 16-year-old human who was adopted by the jellyfish family.
The series premiered on Adult Swim in 2017 and ran for two seasons, with a total of 16 episodes. The show features a unique animation style, with the characters being depicted as jellyfish. The series deals with themes of family, identity, and adolescence, and has been praised for its humor and originality.
Despite its positive reception, "The Jellies!" was canceled after its second season due to low ratings. However, Tyler, The Creator has expressed interest in continuing the series on a different platform, and has stated that he has ideas for future episodes.
"12 oz. Mouse" is an American animated TV show that first aired in 2005. It was created by Matt Maiellaro, who also worked on "Aqua Teen Hunger Force." The show follows the adventures of a strange, alcoholic mouse named Fitz who often finds himself in bizarre situations. The animation style is intentionally crude and surreal, and the show often features strange, nonsensical humor.
The show's plot is often difficult to follow, with nonsensical and absurd storylines. It is also known for its unusual pacing, with scenes often being very short and jumping from one to the next without much explanation. Despite this, the show has gained a cult following and is seen as a cult classic. It has been praised for its unique style and experimental approach to animation.
The show ran for two seasons and a total of 20 episodes. It was initially cancelled after its first season, but due to popular demand, a second season was eventually produced. Although it has not been officially cancelled, there have been no new episodes since 2007. Despite its relatively short run, "12 oz. Mouse" has left a lasting impression on many viewers and has become a beloved part of adult animation history.
Aqua Teen Hunger Force is an American animated television show that aired on Adult Swim from 2000 to 2015. The show follows the adventures of three anthropomorphic fast food items - Master Shake, Frylock, and Meatwad - who live together as roommates in New Jersey. They often find themselves in strange and surreal situations, and their antics are a source of humor throughout the show.
The show was known for its irreverent humor and absurd storylines, which often parodied popular culture and societal norms. It was created by Dave Willis and Matt Maiellaro and quickly gained a cult following due to its unique style and sense of humor.
Over the course of its fifteen-year run, Aqua Teen Hunger Force underwent several title changes and format changes. It was canceled in 2015, but its legacy lives on as one of the most beloved shows to ever air on Adult Swim. The show's unique blend of humor and surrealism continues to influence popular culture and has inspired numerous spin-offs, merchandise, and memes.
Moral Orel is an American stop-motion animated television show that aired on Adult Swim from 2005 to 2008. The show was created by Dino Stamatopoulos and it follows the life of a young boy named Orel Puppington living in the fictional town of Moralton. Orel is raised in a devoutly Christian family and the show often satirizes religious and moral hypocrisy.
The show was controversial due to its dark themes and the way it depicted Christianity. It was often misunderstood by audiences who expected a typical adult-oriented comedy. However, it was praised for its unique storytelling and character development.
The show was canceled after three seasons due to low ratings. However, it gained a cult following and is now considered a cult classic. It has been praised for its ability to tackle difficult topics in a thought-provoking way and for its use of humor to address serious issues.
Harley Quinn is an adult animated TV series that premiered on DC Universe in 2019. It follows the adventures of Harley Quinn, a former psychiatrist who breaks up with the Joker and sets out to become a supervillain in her own right. The series was created by Justin Halpern, Patrick Schumacker, and Dean Lorey.
The show features a talented voice cast, including Kaley Cuoco as Harley Quinn, Lake Bell as Poison Ivy, and Alan Tudyk as the Joker. The series is known for its irreverent humor, over-the-top violence, and sharp writing. It has been praised for its subversive take on superhero tropes and its depiction of a strong, independent female protagonist.
The series has been renewed for a third season, which will air on HBO Max. It has been praised by critics and fans alike for its humor, writing, and voice acting. The show has also been noted for its positive portrayal of LGBTQ+ relationships, particularly the romantic relationship between Harley Quinn and Poison Ivy.
